PRC/EAPC RN study: The European Palliative Care Symptom Study
Palliative care patients are heterogeneous. Evidence based knowledge about the patients and their symptoms may improve clinical practice. To achieve this, an accurate description of the population is needed. Until now, most research on palliative care patients has been conducted with cross-sectional study designs. To gain better understanding on how symptoms, functional status and response to treatment fluctuate during the disease trajectory, a longitudinal multicentre study is planned. Patient reported outcomes, clinical data and biological material will be collected. Principle Investigator (PI) is Marianne Jensen Hjermstad (email@example.com).
Read more about the study here.
PRC/EAPC RN study: Multimodal Cancer Cachexia Intervention Study
Progress in the understanding and treatment of cancer cachexia has been slow. This study is planned as a prospective phase III randomised multicenter clinical trial. The aim of the study is to assess the efficacy and feasibility of a multimodal intervention on cancer cachexia with the focus on nutritional support, exercise and anti-inflammatory treatment. PIs in this study are Ken Fearon and Vickie Baracos. To contribute to this study, please contact Tora S Solheim (firstname.lastname@example.org).
PRC/EAPC RN study: Intrathecal Local Anesthetics and Opioids for Cancer Pain
Intrathecal local anesthetics (LA) and opioids are in some centers used for treatment of severe cancer pain. An EPCRC initiated systematic review showed that the available evidence related to this therapy is very limited. Therefore, the PRC has started to develop a protocol for a randomized controlled study investigating the efficacy of intrathecal LA and opioids.
To contribute to this study, please contact Per Sjøgren (email@example.com) or Pål Klepstad (firstname.lastname@example.org).
PRC/EAPC RN study: RCT Comparing the Analgesic Efficacy in Cancer Patients with Moderate/Severe Pain
The aim of this longitudinal RCT is to evaluate and to compare the performance of four therapeutic strategies based on the use of four strong opioids (fentanyl, oxycodone, buprenorphine vs morphine) in cancer patients, in terms of analgesic efficacy, dose escalation, need of rescue/adjuvant co-treatments and need of switch. The clinical results will be related to genetic profiles of patients based on genome-wide analysis.
This RCT is lead by the Mario Negri Institute, Milan. To contribute please contact PI Oscar Corli (email@example.com).
PRC/EAPC RN study: RCT of Two Step versus Three Step Analgesic Ladder for Cancer Pain Control
The three step WHO analgesic ladder has been key to cancer pain control world-wide, however the role of Step two (weak opioids) has been questioned. A delay in achieving pain control has been identified in cohort studies and in a pilot RCT of a two step versus three step ladder. This study aims to explore whether a two step approach achieves pain control faster but without an excess in opioid toxicity, over a three step approach. To contribute to this study, please contact PI Marie Fallon (firstname.lastname@example.org).
PRC/EAPC RN study: Nasal Fentanyl For Patient Controlled Treatment of Pain in Cancer
This is a research programme going from phase I to phase III to investigate whether cancer pain can be adequately controlled by self administered nasal fentanyl on demand. Thus, this programme challenges the non-proven concept that cancer pain is stable and therefore requires an around the clock fixed dose regimen. To contribute to this study, please contact PI Ola Dale (email@example.com) or Stein Kaasa (firstname.lastname@example.org).
European Palliative Care Research Collaborative (EPCRC)
The European Palliative Care Research Collaborative (EPCRC) is the first major palliative care project within the European Commision’s Framework Programmes. The work includes identification of genetic factors, and development of classification systems, assessment tools and guidelines for three major symptoms and conditions. More…x
European Pharmacogenetic Opioid Study (EPOS)
The study has included 2294 cancer patients treated with opioids for moderate or severe pain; the patients are recruited from 17 centres from 11 European countries. Analysis of the data are initiated and the first publication will be submitted this year. More…
PRISMA: Reflecting the positive diversities of European priorities for research and measurements in end of life care
PRISMA is working collaboratively to identify cultural differences in end of life care, establish a collaborative research agenda informed by public and clinical priorities, and draw together best practice and resources for quality measurement across Europe. More…
PRISMA Work package 3: Clinical Research Priorities in End-of-Life Care
This WP is about to close a pan-European survey on End-of-Life Care Research in Europe. So far they have received more than 100 responses from a total of 36 European countries. The results will be elaborated in an international workshop to outline a future research agenda. More…